Benzenamine, 3-ethynyl- → 6,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine--hydrogen chloride (1/1)

HRID 1288874노트

반응식

HRID 1288874 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:16][CH2:17][CH2:18][Cl:19])=[C:9]([O:12][CH2:13][CH2:14][Cl:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:20]([C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25])#[CH:21]>C(O)(C)C>[ClH:1].[Cl:15][CH2:14][CH2:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:16][CH2:17][CH2:18][Cl:19])[N:5]=[CH:4][N:3]=[C:2]2[NH:25][C:24]1[CH:26]=[CH:27][CH:28]=[C:22]([C:20]#[CH:21])[CH:23]=1

참가 물질

4

반응물 2

HCID 104682Benzenamine, 3-ethynyl-HCID 189250384-Chloro-6,7-bis(2-chloroethoxy)quinazoline

생성물 1

HCID 189250636,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine--hydrogen chloride (1/1)

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
20 °C

실험 절차

4-Chloro-6,7-bis-(2-chloro-ethoxy)-quinazoline (600 mg, 1.87 mmol) and 3-ethynyl-aniline (219 mg, 1.87 mmol) were reacted in refluxing isopropanol (15 mL) under an atmosphere of N2 for 2.5 hours. The mixture was cooled to 20° C. and the precipitated product was filtered, washed With isopropanol and ether and dried in vacuo. (707 mg; 86%; M.P. 230°-240° C. (dec); LC-MS: 402 (MH+); anal. RP18-HPLC RT: 5.35 min.).

후처리

  1. filtrationthe precipitated product was filtered
  2. washwashed With isopropanol and ether
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-31b5e34ec11c47e8a260cac87b5555fd
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747498

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