Guanidine → HCID 15841104, 화합물

HRID 1289214노트

반응식

HRID 1289214 반응식
[CH3:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([C:18]([F:21])([F:20])[F:19])=[CH:7][C:3]=1[C:4](O)=[O:5].CC1C=C(OC2C=CC=CC=2)C(Br)=CC=1C(OC)=O.FC(F)(F)C([O-])=O.[K+].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:61][C:62]([NH2:64])=[NH:63]>[I-].C[N+](C)(C)C.C1COCC1>[NH2:63][C:62]([NH2:64])=[N:61][C:4](=[O:5])[C:3]1[CH:7]=[C:8]([C:18]([F:21])([F:20])[F:19])[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][C:2]=1[CH3:1]

참가 물질

8

반응물 5

HCID 3520GuanidineHCID 682631,1'-CarbonyldiimidazoleHCID 15841102HCID 15841102, 화합물HCID 15841103HCID 15841103, 화합물HCID 23662811Potassium trifluoroacetate

생성물 1

HCID 15841104HCID 15841104, 화합물

시약·촉매·용매 2

HCID 6381Tetramethylammonium iodide촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 0.5 g of 2-methyl-4-phenoxy5-trifluoromethylbenzoic acid [obtainable by reaction of methyl 2-methyl-4-phenoxy-5-bromobenzoate with potassium trifluoroacetate in the presence of Cul and tetramethylammonium iodide and subsequent hydrolysis] and 300 mg of carbonyldiimidazole in 15 ml of THF is stirred at room temperature for two hours and then added to 383 mg of guanidine. The mixture is stirred for a further two hours. After customary working up, N-diaminomethylene-2-methyl-4-phenoxy-5-trifluoromethylbenzamide is obtained.

후처리

  1. stirringThe mixture is stirred for a further two hours

출처 및 근거

ORD 기록
ord-d6bba8111a0248c1b7b81e7ae27eeeac
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747539

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