HCID 178451026, 화합물 → HCID 178451021, 화합물

HRID 1289256노트

반응식

HRID 1289256 반응식
C(OC([NH:11][C@@H:12]([C:22]1[NH:26][N:25]=[N:24][N:23]=1)[CH2:13][CH2:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:11][C@@H:12]([C:22]1[NH:26][N:25]=[N:24][N:23]=1)[CH2:13][CH2:14][C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16]

참가 물질

4

반응물 1

HCID 178451026HCID 178451026, 화합물

생성물 1

HCID 178451021HCID 178451021, 화합물수율 91.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of tert-butyl (4R)-4-(benzyloxycarbonylamino)-4-(tetrazol-5-yl)-butyrate (1.2 g, 3.32 mmol) in ethanol (77 ml) was stirred with 10% Pd-C (0.166 g) under a hydrogen atmosphere at ambient temperature for 16 hours. The catalyst was removed by filtration and the filtrate evaporated. Dichloromethane was added to the residue and evaporated and the resulting solid was triturated with hexane and dried to give tert-butyl (4R)-4-amino-4-(tetrazol-5-yl)butyrate (0.687 g, 91%), m.p. 175° C. (decomp.).

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. additionDichloromethane was added to the residue
  4. customevaporated
  5. customthe resulting solid was triturated with hexane
  6. customdried

출처 및 근거

ORD 기록
ord-c51508cb4cc34c8a94fe0a217ee58be6
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747499

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