HCID 178451023, 화합물 → HCID 178451024, 화합물

HRID 1289257노트

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HRID 1289257 반응식
C(OC([NH:11][C@@:12]([C:36]([CH3:39])([CH3:38])[CH3:37])([C:33]([OH:35])=[O:34])[CH2:13][CH2:14][C:15]([NH:17][C@@H:18]([C:28]1[NH:32][N:31]=[N:30][N:29]=1)[CH2:19][CH2:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[O:16])=O)C1C=CC=CC=1>C(O)C.[Pd]>[C:36]([C@:12]([C:33]([OH:35])=[O:34])([CH2:13][CH2:14][C:15]([NH:17][C@@H:18]([C:28]1[NH:32][N:31]=[N:30][N:29]=1)[CH2:19][CH2:20][C:21]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:22])=[O:16])[NH2:11])([CH3:37])([CH3:38])[CH3:39]

참가 물질

4

반응물 1

HCID 178451023HCID 178451023, 화합물

생성물 1

HCID 178451024HCID 178451024, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매2회HCID 702Ethanol용매

실험 절차

A solution of tert-butyl (4R)-4-{N-[N-(benzyloxycarbonyl)-αtert-butyl-(S)-γ-glutamyl]amino}-4-(tetrazol-5-yl)butyrate (0.320 g, 0.585 mmol) in ethanol (35 ml) was stirred with 10% Pd-C. (0.12 g) under a hydrogen atmosphere at ambient temperature. After 16 hours further 10% Pd-C. (0.09 g) was added and the mixture was stirred under hydrogen for a further 6 hours. It was then filtered through Celite and the filtrate was evaporated. Several portions of dichloromethane were added and evaporated to leave tert-butyl (4R)-4-[N-(α-tert-butyl-(S)-γ-glutamyl)amino]-4-(tetrazol-5-yl)butyrate as a crisp, colourless glass which was dried over phosphorus pentoxide and used without further purification. Yield 0.24 g; m.p. 92°-94° C.

후처리

  1. customat ambient temperature
  2. addition(0.09 g) was added
  3. filtrationIt was then filtered through Celite
  4. customthe filtrate was evaporated
  5. additionSeveral portions of dichloromethane were added
  6. customevaporated

출처 및 근거

ORD 기록
ord-143e9a10dba040e482c45ccd8a811331
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747499

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