Pyridine → HCID 18921566, 화합물
반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[CH:6]2.[Br:15]Br.N1C=CC=CC=1>ClC(Cl)(Cl)Cl>[Br:15][C:7]1[CH:8]=[N:9][C:10]2[C:5]([CH:6]=1)=[CH:4][C:3]([C:2]([F:1])([F:13])[F:14])=[CH:12][CH:11]=2참가 물질
5
실험 절차
19.7 g of 6-trifluoromethyl-quinoline is introduced into 200 ml of tetrachloromethane. 5.2 ml of bromine is instilled and the solution is refluxed for one hour. Within twenty minutes, 7.9 g of pyridine in 8 ml of tetrachloromethane is instilled in the boiling solution. After one hour, it is allowed to cool, decanted from the precipitated salt and the solution is concentrated by evaporation. After column chromatography, 14.6 g of 3-bromo-6-trifluoromethyl-quinoline of melting point 79° C. is obtained.
후처리
- temperaturethe solution is refluxed for one hour
- waitWithin twenty minutes
- temperatureto cool
- customdecanted from the precipitated salt
- concentrationthe solution is concentrated by evaporation
출처 및 근거
- ORD 기록
- ord-5dcd0cc6b6b646d4b45637753ec9eb4b
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05750526
반응 노트
불러오는 중…