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Triethylamine → HCID 23206536, 화합물

HRID 1289429
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HRID 1289429 반응식
C(N(CC)CC)C.[CH2:8]([O:10][P:11]([O-:15])[O:12][CH2:13][CH3:14])[CH3:9].Br[C:17]1[CH:18]=[N:19][C:20]2[C:25]([CH:26]=1)=[CH:24][C:23]([C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=2>C1(C)C=CC=CC=1.CCOCC.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd]>[CH2:8]([O:10][P:11]([C:17]1[CH:18]=[N:19][C:20]2[C:25]([CH:26]=1)=[CH:24][C:23]([C:27]([F:29])([F:30])[F:28])=[CH:22][CH:21]=2)(=[O:15])[O:12][CH2:13][CH3:14])[CH3:9]
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참가 물질

7

반응물 3

HCID 8471TriethylamineHCID 3780918DiethylphosphiteHCID 18921566HCID 18921566, 화합물

생성물 1

HCID 23206536HCID 23206536, 화합물

시약·촉매·용매 3

HCID 11979704Tetrakis(triphenylphosphine)palladium촉매HCID 1140Toluene용매
HCID 3283
Diethyl Ether
용매

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온도
90 °C

실험 절차

1.44 g of tetrakis-(triphenylphosphine)-palladium(O) are introduced in 16 ml of toluene, 3.8 ml of triethylamine and 3.6 ml of diethylphosphite at room temperature under nitrogen and mixed with 6.90 g of 3-bromo-6-trifluoromethyl-quinoline. It is stirred for two hours at 90° C. bath temperature. The mixture is diluted with ether, suctioned off and the filtrate is concentrated by evaporation. After column chromatography, 8.3 g of 6-trifluoromethyl-quinoline-3-phosphonic acid diethyl ester of melting point 69° C. is obtained.

후처리

  1. concentrationthe filtrate is concentrated by evaporation

출처 및 근거

ORD 기록
ord-eac2a190f7824a27b7782a8ee081630f
출처 데이터셋
uspto-grants-1998_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05750526

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