Pivaloyl chloride → Nalbuphine pivalate

HRID 1289466노트

반응식

HRID 1289466 반응식
[CH:1]1[C:6]2[CH2:7][C@H:8]3[N:13]([CH2:14][CH:15]4[CH2:18][CH2:17][CH2:16]4)[CH2:12][CH2:11][C@:10]45[C@H:19]([C@@H:21]([OH:24])[CH2:22][CH2:23][C@@:9]34[OH:25])[O:20][C:4]([C:5]=25)=[C:3]([OH:26])[CH:2]=1.[C:27](Cl)(=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29]>C(Cl)Cl>[CH:1]1[C:6]2[CH2:7][C@H:8]3[N:13]([CH2:14][CH:15]4[CH2:18][CH2:17][CH2:16]4)[CH2:12][CH2:11][C@:10]45[C@H:19]([C@@H:21]([OH:24])[CH2:22][CH2:23][C@@:9]34[OH:25])[O:20][C:4]([C:5]=25)=[C:3]([OH:26])[CH:2]=1.[C:27]([O-:32])(=[O:20])[C:28]([CH3:31])([CH3:30])[CH3:29]

참가 물질

4

반응물 2

HCID 62493Pivaloyl chlorideHCID 5311304Nalbuphine

생성물 1

HCID 86752539Nalbuphine pivalate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

75 mL of methylene chloride and 3.75 g (0.01 mole) of nalbuphine were placed in a 250-mL ice-bathed round-bottomed flask. While stirring, 0.01 mole of pivaloyl chloride dissolved in 20 mL of methylene chloride was added gradually. Following the procedure as described in Example 1, pure nalbuphine pivalate was obtained. The physical data are shown in Table 1 and FIGS. 6, 7 and 8.

후처리

  1. additionwas added gradually

출처 및 근거

ORD 기록
ord-2b1094df3d994fc5a56eaef7e40d4eca
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750534

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