(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indole → (+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine

HRID 128968

반응식

HRID 128968 반응식
O=C1[NH:6][CH:5]([CH2:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[CH:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)[C:4](=[O:24])N1.[OH2:25].[OH-].[Ba+2].[OH-]>O>[CH3:23][N:20]1[CH2:21][CH2:22][CH:17]([C:11]2[C:10]3[C:14](=[CH:15][CH:16]=[C:8]([CH2:7][C@@H:5]([C:4]([OH:24])=[O:25])[NH2:6])[CH:9]=3)[NH:13][CH:12]=2)[CH2:18][CH2:19]1

참가 물질

4

반응물 2

HCID 15233277(+/-)-5-(2,5-Dioxo-4-imidazolidinylmethyl)-3-(1-methyl-4-piperidyl)-1H-indoleHCID 17749100Barium hydroxide, monohydrate

생성물 1

HCID 22852202(+/-)-3-[3-(1-Methyl-4-piperidyl)-1H-indol-5-yl]alanine수율 58.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of the product from step (d) (2.4 g) and barium hydroxide hydrate (8.4 g) in water (50 ml) was refluxed for 72 hours, then cooled and evaporated in vacuo. The residue was taken up in hot methanol and filtered to remove barium salts. The filtrate was evaporated in vacuo, the residue dissolved in water and dry ice added to precipitate barium carbonate. The latter was filtered off and the filtrate evaporated in vacuo to give the desired product as a yellow foam (1.3 g).

후처리

  1. temperaturecooled
  2. customevaporated in vacuo
  3. filtrationfiltered
  4. customto remove barium salts
  5. customThe filtrate was evaporated in vacuo
  6. dissolutionthe residue dissolved in water
  7. additiondry ice added
  8. customto precipitate barium carbonate
  9. filtrationThe latter was filtered off
  10. customthe filtrate evaporated in vacuo

출처 및 근거

ORD 기록
ord-1ed5480966f7465eb26b1e10832e79ae
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05466699

연결된 노트

불러오는 중…