HCID 10339510, 화합물 → HCID 10607909, 화합물
반응식
NC1N=[C:5]([C:7]2C=[C:11](C(C)(C)C)[C:10](OCOCCOC)=[C:9](C(C)(C)C)[CH:8]=2)[NH:4]N=1.C[O-].[Na+].CO.[C:33]([NH:36][NH2:37])([NH2:35])=[NH:34].[ClH:38]>CO>[NH2:34][C:33]1[N:35]=[C:11]([C:10]2[CH:9]=[CH:8][C:7]([Cl:38])=[CH:5][N:4]=2)[NH:37][N:36]=1참가 물질
5
실험 절차
The synthesis method of Example 7-(2) was applied. The compound (3.94 g) obtained in (3) above, a 5M sodium methoxide-methanol solution (17 ml), methanol (20 ml) and aminoguanidine hydrochloride (9.39 g) were used as reagents. The mixture was stirred with refluxing for 18 hours and methanol was distilled away under reduced pressure. Water was added to the residue and the aqueous layer was adjusted to pH 3-4 with 3N hydrochloric acid to give 3.40 g of a pale-yellow solid that precipitated (yield 82%).
후처리
- temperaturewith refluxing for 18 hours
- distillationmethanol was distilled away under reduced pressure
- additionWater was added to the residue
출처 및 근거
- ORD 기록
- ord-611c5913e9194cf5b626e48d685ad9c3
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05750545
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