Potassium Hydroxide → Potassium 4-hydroxy-2,2-dimethylbutyrate

HRID 1289871

반응식

HRID 1289871 반응식
[CH3:1][C:2]1([CH3:8])[CH2:7][CH2:6][O:5][C:3]1=[O:4].[OH-:9].[K+:10]>O>[K+:10].[OH:5][CH2:6][CH2:7][C:2]([CH3:8])([CH3:1])[C:3]([O-:9])=[O:4]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 947462,2-Dimethyl-4-butyrolactone

생성물 1

HCID 23712640Potassium 4-hydroxy-2,2-dimethylbutyrate수율 87%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2,2-dimethylbutyrolactone (8.17 g, 71.7 mmol) and KOH (4.02 g,71.7 mmol) in 72 ml of water was refluxed overnight and then the mixture was concentrated in vacuo (50° C.). The crude residual oil was crystallized in ethanol/ether and the resulting white solid product was filtered and dried (100° C./0.1 mm) to afford 10.6 g (87%) of 4-hydroxy-2.2-dimethylbutyric acid monopotassium salt.

후처리

  1. temperaturewas refluxed overnight
  2. concentrationthe mixture was concentrated in vacuo (50° C.)
  3. customThe crude residual oil was crystallized in ethanol/ether
  4. filtrationthe resulting white solid product was filtered
  5. customdried (100° C./0.1 mm)

출처 및 근거

ORD 기록
ord-2be3c2878973479eba9f42c26023efa2
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750550

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