Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diazomethane → Methyl indole-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diazomethane | HCID 9550 | — |
| 반응물 | Indole-3-Carboxylic Acid | HCID 69867 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl indole-3-carboxylate | HCID 589098 | — |
반응 단계
Indole-3-carboxylic acid (757 mg, 4.7 mmol, 1.0 eq.) was partially dissolved in a mixture of ether, ethyl acetate and methanol. While stirring, a solution of diazomethane in ether was added until a yellow color persisted. The solvent was removed in vacuo and the remaining white solid was passed through a silica gel column, eluting with dichloromethane to give the title A compound (819 mg), m.p. 147°-149° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05466704 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-1c8c10f69faf4487bee50351a9363e9b |
| 출처 메모 | uspto-grants-1995_11 |