Methanol → 1-(Bromomethyl)-2-methanesulfonylbenzene
반응식
CS[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][Br:6].O[O:12][S:13]([O-:15])=O.[K+].[CH3:17]O>O>[CH3:17][S:13]([C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][Br:6])(=[O:15])=[O:12]참가 물질
5
실험 절차
To a solution of 124 mg (0.57 mmol) of 2-(methylthio)-benzylbromide in 8.0 mL of methanol was added a solution of 702 mg of oxone in 7.0 mL of water. The solution was stirred for 4.5 h, concentrated in vacuo and purified by silica gel flash chromatography, eluting with 10% ethyl acetate/hexane to give 105 mg of the title compound. mass spec 249(M+). NMR (CDCl3): δ 3.25 (s, 3H), 5.07 (s, 2H), 7.50 (m, 1H), 7.60 (m, 2H), 8.05 (d, 1H).
후처리
- concentrationconcentrated in vacuo
- custompurified by silica gel flash chromatography
- washeluting with 10% ethyl acetate/hexane
출처 및 근거
- ORD 기록
- ord-11363b0229f34597bd9f6f342ba64980
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05750549
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