Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl 2-acetylglutarate → Ethyl 3-(6-Methyl-2-methoxymethyl-3H-pyrimidin-4-on-5-yl)propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl 2-acetylglutarate | HCID 73915 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | 2-Methoxyethanimidamide hydrochloride | HCID 13548602 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 3-(6-Methyl-2-methoxymethyl-3H-pyrimidin-4-on-5-yl)propionate | HCID 136067006 | 42% |
반응 단계
A mixture of NaOEt (0.088 mol) in EtOH (prepared from 2.0 g of Na and 70 mL of EtOH), methoxyacetamidine hydrochloride (5.4 g, 0.044 mol), and diethyl acetylglutarate (10.0 g, 0.044 mol) was heated under reflux for 24 h. The mixture was concentrated, taken up in water, acidified to pH 4 with conc. HCl, and extracted with CH2Cl2. The extracts were washed with brine, dried (MgSO4), and concentrated. Trituration with ether gave 4.6 g (42%) of product as an off-white solid, mp 87°-90° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05466692 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-2e0daf3a169947c4b577469e4a661227 |
| 출처 메모 | uspto-grants-1995_11 |