Hydrogen chloride-ethyl acetate → HCID 178485752, 화합물

HRID 1290075노트

반응식

HRID 1290075 반응식
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:50].C(OCC)(=O)C>C(O)C.C(OCC)(=O)C>[ClH:50].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178485751HCID 178485751, 화합물

생성물 1

HCID 178485752HCID 178485752, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

The compound (300 mg) obtained in Example 1 was dissolved in a mixed solution of ethanol (0.27 ml) and ethyl acetate (5.13 ml) and a solution (2.09 ml) of 0.2N HCl-ethyl acetate was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 160 mg of the title compound as white crystals (see Table 16).

후처리

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-be4c5262dd7f4eb88194f8caa7e5fe14
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750696

반응 노트

불러오는 중…