2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) → HCID 178485755, 화합물

HRID 1290076노트

반응식

HRID 1290076 반응식
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.[C:51]([OH:63])(=[O:62])[CH2:52][C:53]([CH2:58][C:59]([OH:61])=[O:60])([C:55]([OH:57])=[O:56])[OH:54]>C(OCC)(=O)C>[C:51]([OH:63])(=[O:62])[CH2:52][C:53]([CH2:58][C:59]([OH:61])=[O:60])([C:55]([OH:57])=[O:56])[OH:54].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 222302-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1)HCID 178485751HCID 178485751, 화합물

생성물 1

HCID 178485755HCID 178485755, 화합물수율 66.8%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

The compound (300 mg) obtained in Example 1 was dissolved in ethyl acetate (3 ml) and a solution of citric acid monohydrate (92.7 mg) in ethyl acetate (5 ml) was dropwise added. After stirring at room temperature for 15 minutes, crystals were collected by filtration and dried under reduced pressure to give 257 mg of the title compound as white crystals (see Table 16).

후처리

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ac2956440f2c436b8061b3693b6a8fb3
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750696

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