Methanesulfonic Acid → HCID 178485753, 화합물

HRID 1290078노트

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HRID 1290078 반응식
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:50][S:51]([OH:54])(=[O:53])=[O:52]>C(OCC)(=O)C.C(O)C>[CH3:50][S:51]([OH:54])(=[O:53])=[O:52].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 6395Methanesulfonic AcidHCID 178485751HCID 178485751, 화합물

생성물 1

HCID 178485753HCID 178485753, 화합물수율 82.5%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매2회

실험 절차

The compound (310 mg) obtained in Example 1 was dissolved in ethyl acetate (7 ml) and a solution of methanesulfonic acid (44 mg) in ethyl acetate (5 ml) and ethanol (0.25 ml) was dropwise added. After stirring at room temperature for 3 hours, crystals were collected by filtration and dried under reduced pressure to give 292 mg of the title compound as white crystals (see Table 16).

후처리

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-0154a20d7b3042f2a22beff0c0920b96
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750696

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