Maleic Acid → HCID 178485754, 화합물

HRID 1290079노트

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HRID 1290079 반응식
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54]>C(OCC)(=O)C.C(O)C>[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 444266Maleic AcidHCID 178485751HCID 178485751, 화합물

생성물 1

HCID 178485754HCID 178485754, 화합물수율 79.8%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매2회

실험 절차

The compound (778 mg) obtained in Example 1 was dissolved in ethyl acetate (10 ml) and a solution of maleic acid (132 mg) in ethyl acetate (15.5 ml) and ethanol (1.55 ml) was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 723 mg of the title compound as white crystals (see Table 17).

후처리

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-902c1afeed5b40b48f9435e57e378e33
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750696

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