Ammonia → 2-Amino-3,6-dichloro-5-trifluoromethylpyridine

반응식

[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([Cl:12])=[C:4](OC)[N:3]=1.[NH3:15]>>[NH2:15][C:4]1[C:5]([Cl:12])=[CH:6][C:7]([C:8]([F:11])([F:10])[F:9])=[C:2]([Cl:1])[N:3]=1

참가 물질

반응물 2

HCID 222Ammonia

HCID 186895102,5-Dichloro-6-methoxy-3-trifluoromethylpyridine

생성물 1

HCID 130641542-Amino-3,6-dichloro-5-trifluoromethylpyridine

실험 절차

If, in contrast, the novel 2,5-dichloro-6-methoxy-3-trifluoromethylpyridine is reacted with ammonia, the undesired 2-amino-3,6-dichloro-5-trifluoromethylpyridine is predominantly formed while the methoxy group is lost.

출처 및 근거

ORD 기록: ord-405f63be2b7e4091b041156611df823b
출처 데이터셋: uspto-grants-1998_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05750705

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