1-Butanaminium, N,N,N-tributyl-, azide → Ethanethioic acid trans-(+/-)S-[5-(azidomethyl)tetrahydro-3-furanyl]ester
반응식
FC(F)(F)S(O[CH2:7][C@@H:8]1[O:12][CH2:11][C@@H:10]([S:13][C:14](=[O:16])[CH3:15])[CH2:9]1)(=O)=O.[N-:19]=[N+:20]=[N-:21].C([N+](CCCC)(CCCC)CCCC)CCC>C(Cl)Cl>[N:19]([CH2:7][C@@H:8]1[O:12][CH2:11][C@@H:10]([S:13][C:14](=[O:16])[CH3:15])[CH2:9]1)=[N+:20]=[N-:21]참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
To a 0° C. solution of 5.768 g of product from Example 22 in 16 ml of methylene chloride, under argon, is added, via syringe, a 0° C. solution of 5.86 g of tetrabutylammonium azide in 16 ml of methylene chloride. The reaction is stirred in an ice bath for 30 minutes and then concentrated in vacuo. The residue is purified by chromatography (Silica Gel: 50% ethyl acetate/hexane) to give 3.418 g of the desired product.
후처리
- concentrationconcentrated in vacuo
- customThe residue is purified by chromatography (Silica Gel: 50% ethyl acetate/hexane)
출처 및 근거
- ORD 기록
- ord-d73c3b7ef6c0444da33e3e284a54f9e3
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05750735
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