Tetrahydrofuran → 5-(2,4-Difluorophenyl)tetrahydro-3-furanthiol

HRID 1290408노트

반응식

HRID 1290408 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[O:13][CH2:12][CH:11]([S:14]C(=O)C)[CH2:10]1.C[O-].[Na+].CO.O1CCCC1.Cl.C(O)(C)C>C(OCC)(=O)C.CCCCCC>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[O:13][CH2:12][CH:11]([SH:14])[CH2:10]1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 21912024Isopropanol hydrochlorideHCID 23694274Sodium methanolate methanolHCID 85719043(+/-)-Ethanethioic acid S-[5-(2,4-difluorophenyl)tetrahydro-3-furanyl]ester

생성물 1

HCID 189239905-(2,4-Difluorophenyl)tetrahydro-3-furanthiol수율 86%

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

The title compound is prepared by the procedure of Example 16 using 0.250 g of product from Example 166, 243 μl of 25% sodium methoxide/methyl alcohol, 4.5 ml of tetrahydrofuran and 530 μl of 2N hydrochloric acid/isopropyl alcohol to give, after chromatography (silica gel: 5-10% ethyl acetate/hexane), 0.180 g of the desired product, as a mixture of isomers.

후처리

  1. customto give

출처 및 근거

ORD 기록
ord-489358265b594cae8ab612555f8db3df
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750735

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