Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → 2-Methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine | HCID 11345458 | — |
| 반응물 | 4-(Benzyloxy)-3-hydroxybenzonitrile | HCID 15453451 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine | HCID 22102986 | 56.1% |
반응 단계
To 4,6-dichloro-5-nitro-2-methylthiopyrimidine (5.0 g, 20.8 mmol) in 200 mL acetonitrile at 0° C. was added cesium carbonate (8.82 g, 27.1 mmol) followed by the addition of 3-hydroxy-4-benzyloxybenzonitrile (4.69 g, 20.8 mmol), and the resulting reaction mixture was stirred for 16 hours. The volatiles were evaporated and the residue chromatographed on silica gel (hexane/ethyl acetate, 2:1) to afford 5.0 g of 2-methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine, a compound of formula (C).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753635 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-0b7ff376d41f4e619d1270c59be0e6ba |
| 출처 메모 | uspto-grants-1998_05 |