Ethyl 4-(2-nitrophenoxy)butanoate → Ethyl 4-(2-aminophenoxy)butanoate

HRID 1290707노트

반응식

HRID 1290707 반응식
[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])([O-])=O.[H][H]>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11]

참가 물질

5

반응물 2

HCID 12433959Ethyl 4-(2-nitrophenoxy)butanoateHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 11816929Ethyl 4-(2-aminophenoxy)butanoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of (3) (1.27 g, 5.0 mM) in 15 mL ethyl acetate containing 200 mg of 57% palladium on carbon is reacted in a hydrogen atmosphere (40 psig.) at room temperature until hydrogen uptake ceases. The mixture is then filtered and concentrated in vacuo to yield 1.0+g of (4) as an oil/low melting solid.

후처리

  1. filtrationThe mixture is then filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9baa62f910444cf4b3689380998508bb
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753641

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