1-Chloro-1-penten-3-one → 7-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1290801노트

반응식

HRID 1290801 반응식
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.Cl[CH:8]=[CH:9][C:10](=O)[CH2:11][CH3:12]>C(O)(=O)C>[CH2:11]([C:10]1[N:3]2[N:4]=[CH:5][N:6]=[C:2]2[N:1]=[CH:8][CH:9]=1)[CH3:12]

참가 물질

4

반응물 2

HCID 30420161-Chloro-1-penten-3-oneHCID 178418311HCID 178418311, 화합물

생성물 1

HCID 189193537-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 3-amino-1,2,4-triazole (11.74 g) and 1-chloro-1-penten-3-one (16.5 g) in acetic acid (225 ml) was heated under reflux for 45 minutes. The reaction mixture was cooled, poured onto ice and extracted with dichloromethane. The organic layer was dried and the solvent was evaporated under reduced pressure to give 7-ethyl-1,2,4-triazolo[1,5-a]pyrimidine. Yield 11.72 g.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 45 minutes
  3. temperatureThe reaction mixture was cooled
  4. additionpoured onto ice
  5. extractionextracted with dichloromethane
  6. customThe organic layer was dried
  7. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-0aa344644dc74068b60e34c3e9ed934b
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753665

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