Potassium Hydroxide → HCID 13565856, 화합물

HRID 1290884노트

반응식

HRID 1290884 반응식
Cl.[NH2:2][CH:3]1[CH2:9][CH:8]2[NH:10][CH:5]([CH2:6][CH2:7]2)[CH2:4]1.[OH-].[K+]>C(O)C>[NH2:2][CH:3]1[CH2:4][CH:5]2[NH:10][CH:8]([CH2:7][CH2:6]2)[CH2:9]1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 18919578HCID 18919578, 화합물

생성물 1

HCID 13565856HCID 13565856, 화합물수율 35.7%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

After completion of the hydrogenation, insoluble matters were filtered off and 40 ml of conc. hydrochloric acid was added to the filtrate. The solvent was distilled off under vacuum and the residue was recrystallized from ethanol to give 8.3 g of 3-amino-8-azabicyclo[3.2.1]octane hydrochloride. After 8.3 g of the hydrochloride was added to 100 ml of ethanol, a solution of 5.2 g of potassium hydroxide in 50 ml of ethanol was added to the mixture followed by stirring at room temperature for 3 hours. Insoluble matters were filtered off and the solvent was then distilled off to give 2.3 g of 3-amino-8-azabicyclo[3.2.1]octane.

후처리

  1. filtrationInsoluble matters were filtered off
  2. distillationthe solvent was then distilled off

출처 및 근거

ORD 기록
ord-f61dbc2b477d4411ac458a90a82b4fd3
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753673

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