Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Malonate → Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Isopropylaminobenzaldehyde hydrochloride | HCID 18919624 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate | HCID 15468682 | 147.4% |
반응 단계
A solution of 133.7 g of 2-isopropylaminobenzaldehyde hydrochloride, 200 g of diethyl malonate, 70 ml of piperidine, 70 ml of acetic acid, 50 g of potassium carbonate and 1.5 liter of toluene was heated to reflux for 10 hours. The reaction solution was washed with water and then with saturated sodium hydrogencarbonate aqueous solution, and dried over anhydrous magnesium sulfate. The solvent was distilled off to give 256 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate as the crude product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753673 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-0b38fcc32af04d938445b2572f71a4d6 |
| 출처 메모 | uspto-grants-1998_05 |