Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-((Propan-2-yl)amino)benzaldehyde | HCID 11041035 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate | HCID 15468682 | 163.7% |
반응 단계
A solution of 20.0 g of 2-isopropylaminobenzaldehyde, 29.4 g of diethyl malonate, 10 ml of piperidine, 10 ml of acetic acid and 500 ml of toluene was heated to reflux for 13 hours. The reaction solution was washed with water and then with saturated sodium hydrogencarbonate aqueous solution, and dried over anhydrous magnesium sulfate. The solvent was distilled off to give 52 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate as the crude product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753673 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-25437f40d43f43cbb58bd11a5bdc9e43 |
| 출처 메모 | uspto-grants-1998_05 |