Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Dimethylaminopyridine → 1-Benzyl-piperidin-4-yl 2-dimethylamino-benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | 2-(Dimethylamino)benzoic acid | HCID 69118 | — |
| 반응물 | 1-Benzylpiperidin-4-ol | HCID 78461 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Benzyl-piperidin-4-yl 2-dimethylamino-benzoate | HCID 18919776 | 46% |
반응 단계
0.33 g (0.002 mol) of 2-dimethylaminobenzoic acid was dissolved in 10 ml of dimethylformamide, treated with 0.122 g (0.001 mol) of dimethylaminopyridine and 0.383 g (0.002 mol) of 1-benzyl-4-hydroxypiperidine and cooled to 0°. 0.422 g (0.0022 mol) of N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide hydrochloride was added and the mixture was stirred at 0° for a further 2 hrs. Subsequently, the mixture was stirred at room temperature for 3 days, the solvent was distilled off and the residue was chromatographed on silica gel with ethyl acetate/hexane (1:2). 0.31 g (46%) of 1-benzyl-piperidin-4-yl 2-dimethylamino-benzoate was obtained as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753679 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-79eaf0e3929f46ba9c6fd28300d0b724 |
| 출처 메모 | uspto-grants-1998_05 |