3-Bromobenzyl bromide → 1-(3-Bromobenzyl)piperidin-4-ol

HRID 1291129노트

반응식

HRID 1291129 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12]Br>CN(C)C=O>[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][N:5]1[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]1

참가 물질

4

반응물 2

HCID 699793-Bromobenzyl bromideHCID 79341Piperidin-4-ol

생성물 1

HCID 7652181-(3-Bromobenzyl)piperidin-4-ol수율 96.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.202 g (0.002 mol) of 4-hydroxypiperidine and 0.55 g (0.0022 mol) of 3-bromobenzyl bromide were dissolved in 5 ml of dimethylformamide and stirred at room temperature for 2 hrs. The solvent was distilled off and the residue was taken up in dichloromethane and washed with saturated bicarbonate solution and sodium chloride solution. The organic phase was dried over sodium sulfate and concentrated. 0.52 g (96%) 1-(3-bromo-benzyl)-piperidin-4-ol was obtained as a brown oil. MS: me/e (% basic peak)=271, 269 (C12H16BrNO+, 26, 26.6), 270, 268 (25.5, 22), 171, 169 (47, 48.3), 114 (76.6), 100 (100).

후처리

  1. distillationThe solvent was distilled off
  2. washwashed with saturated bicarbonate solution and sodium chloride solution
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e9bc74bbf57b4aff85256636a10ac1a1
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753679

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