홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Carbonate → 3-Methyl-2-[4-[6-(4-piperidinopiperidino)nicotinoyl]benzylthio]-4H-pyrido[1,2-a]pyrimidin-4-one trihydrochloride

HRID 1291390
노트
인쇄 미리보기

반응식

HRID 1291390 반응식
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([C:8]2[CH:27]=[CH:26][C:11]([CH2:12][S:13][C:14]3[N:15]=[C:16]4[CH:25]=[CH:24][CH:23]=[CH:22][N:17]4[C:18](=[O:21])[C:19]=3[CH3:20])=[CH:10][CH:9]=2)=[O:7])=[CH:4][N:3]=1.[N:30]1([CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[ClH:1].[ClH:1].[ClH:1].[CH3:20][C:19]1[C:18](=[O:21])[N:17]2[CH:22]=[CH:23][CH:24]=[CH:25][C:16]2=[N:15][C:14]=1[S:13][CH2:12][C:11]1[CH:26]=[CH:27][C:8]([C:6](=[O:7])[C:5]2[CH:28]=[CH:29][C:2]([N:39]3[CH2:40][CH2:41][CH:36]([N:30]4[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]4)[CH2:37][CH2:38]3)=[N:3][CH:4]=2)=[CH:9][CH:10]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 786071,4'-BipiperidineHCID 189190212-[4-(6-Chloronicotinoyl]benzylthio]-3-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 189189983-Methyl-2-[4-[6-(4-piperidinopiperidino)nicotinoyl]benzylthio]-4H-pyrido[1,2-a]pyrimidin-4-one trihydrochloride수율 18.6%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A solution of 2-[4-(6-chloronicotinoyl)benzylthio]-3-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one (287 mg), 4-piperidinopiperidine (137 mg) and potassium carbonate (194 mg) in DMF (10 ml) was stirred at 80° C. for 24 hours. This reaction mixture was concentrated and the residue was dissolved in chloroform. The solution was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (chloroform-methanol =9:1) and treated with hydrogen chloride/ethyl acetate to provide the title compound as colorless solid (28 mg).

후처리

  1. concentrationThis reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in chloroform
  3. washThe solution was washed with water
  4. customdried
  5. concentrationconcentrated
  6. customThe residue was purified by silica gel column chromatography (chloroform-methanol =9:1)
  7. additiontreated with hydrogen chloride/ethyl acetate

출처 및 근거

ORD 기록
ord-07e5dac7407b4e19b143ddc6d00b9848
출처 데이터셋
uspto-grants-1998_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05753664

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트