Potassium Carbonate → 3-Methyl-2-[4-[4-(4-phenylpiperazinylmethyl)-benzoyl]benzylthio]-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1291391노트

반응식

HRID 1291391 반응식
[SH:1][C:2]1[N:3]=[C:4]2[CH:13]=[CH:12][CH:11]=[CH:10][N:5]2[C:6](=[O:9])[C:7]=1[CH3:8].Br[CH2:15][C:16]1[CH:31]=[CH:30][C:19]([C:20]([C:22]2[CH:27]=[CH:26][C:25]([CH2:28]Br)=[CH:24][CH:23]=2)=[O:21])=[CH:18][CH:17]=1.Cl.[C:33]1([N:39]2[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:8][C:7]1[C:6](=[O:9])[N:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[S:1][CH2:15][C:16]1[CH:31]=[CH:30][C:19]([C:20](=[O:21])[C:22]2[CH:27]=[CH:26][C:25]([CH2:28][N:42]3[CH2:43][CH2:44][N:39]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH2:40][CH2:41]3)=[CH:24][CH:23]=2)=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 751641-Phenylpiperazinium chlorideHCID 23039244,4'-Bis(bromomethyl)benzophenoneHCID 189188982-mercapto-3-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 189188383-Methyl-2-[4-[4-(4-phenylpiperazinylmethyl)-benzoyl]benzylthio]-4H-pyrido[1,2-a]pyrimidin-4-one수율 16.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 2-mercapto-3-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (298 mg), 4,4'-bis(bromomethyl)benzophenone (934 mg), phenylpiperazine hydrochloride (402 mg) and potassium carbonate (850 mg) in DMF (30 ml) was stirred at room temperature for 10 hours. This reaction mixture was concentrated and the residue was dissolved in chloroform, washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:1) to provide the title compound as colorless solid (146 mg).

후처리

  1. concentrationThis reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in chloroform
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated
  6. customThe residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:1)

출처 및 근거

ORD 기록
ord-53b480fb6d644aada34800c6e783f814
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753664

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