Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 7-[4-(4-Chlorobenzoyl)benzyl]-3-methyl-1-propylxanthine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Iodopropane | HCID 33643 | — |
| 반응물 | 3-Methyl-7-[4-(4-chlorobenzoyl)benzyl]xanthine | HCID 18918801 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-[4-(4-Chlorobenzoyl)benzyl]-3-methyl-1-propylxanthine | HCID 18919007 | 48.4% |
반응 단계
A solution of 3-methyl-7-[4-(4-chlorobenzoyl)benzyl]xanthine (657 mg), potassium carbonate (242 mg) and propyl iodide (427 mg) in DMF (10 ml) was stirred at 60° C. for 5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried, and concentrated. The residue was purified by silica gel column chromatography (hexane-ethyl acetate =1:1) and recrystallized from ethyl acetate to provide the title compound as colorless solid (352 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753664 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-4988ba6bbf1e484989f3db1b12a121fc |
| 출처 메모 | uspto-grants-1998_05 |