Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropyl iodide → 7-[4-(4-Chlorobenzoyl)benzyl]-1-isopropyl-3-methylxanthine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropyl iodide | HCID 6362 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Methyl-7-[4-(4-chlorobenzoyl)benzyl]xanthine | HCID 18918801 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-[4-(4-Chlorobenzoyl)benzyl]-1-isopropyl-3-methylxanthine | HCID 18919245 | 6.3% |
반응 단계
A solution of 3-methyl-7-[4-(4-chlorobenzoyl)-benzyl]xanthine (544 mg), potassium carbonate (202 mg) and isopropyl iodide (356 mg) in DMF (10 ml) was stirred at 60° C. for 5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:1) and recrystallized from acetone-hexane to provide the title compound as colorless solid (38 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753664 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-bcf7b3611c324a34a886238f54b510c8 |
| 출처 메모 | uspto-grants-1998_05 |