참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 12-Aminododecanoic Acid | HCID 69661 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 12-aminododecanoate | HCID 3665980 | 95% |
반응 단계
To a 3-l flask equipped with a stirrer, 200.0 g (0.93 mol) of 12-aminododecanoic acid, 600 g of methanol and 100 g (1.0 mol) of sulfuric acid were charged, followed by stirring at 60° C. for 5 hours. After the reaction mixture was allowed to cool down, it was diluted with methylene chloride, followed by neutralization with an aqueous solution of sodium carbonate. The solvent was distilled off under reduced pressure, followed by purification by chromatography on an alumina short column, whereby 201.7 g of the title compound (7-a) were obtained (yield: 95%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05753707 |
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| 출처 데이터셋 | uspto-grants-1998_05 |
|---|
| ORD ID | ord-65d1920ed434425f8e8e578931e129a0 |
|---|
| 출처 메모 | uspto-grants-1998_05 |
|---|
