6-Hydroxyquinoline → Methyl 4-(6-quinolyloxy)-3-methylsulfonylbenzoate

HRID 1291703노트

반응식

HRID 1291703 반응식
Cl[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[S:12]([CH3:15])(=[O:14])=[O:13].[OH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][CH:21]=[CH:20]2.C([O-])([O-])=O.[K+].[K+].C([O-])(O)=O.[Na+]>CN(C=O)C>[N:23]1[C:24]2[C:19](=[CH:18][C:17]([O:16][C:2]3[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=3[S:12]([CH3:15])(=[O:14])=[O:13])=[CH:26][CH:25]=2)[CH:20]=[CH:21][CH:22]=1

참가 물질

6

반응물 4

HCID 113746-HydroxyquinolineHCID 11430Potassium CarbonateHCID 516892Sodium BicarbonateHCID 10490815Methyl 4-chloro-3-(methylsulfonyl)benzoate

생성물 1

HCID 19360547Methyl 4-(6-quinolyloxy)-3-methylsulfonylbenzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2 mmol of methyl 4-chloro-3-methylsulfonylbenzoate, 2 mmol of 6-hydroxyquinoline and 6 mmol of K2CO3 were stirred at 130° C. for 2 h in 20 ml of DMF (anhydrous). The mixture was then poured into 100 ml of saturated aqueous NaHCO3 solution and extracted 3 times with 100 ml of EA. The extract was dried over Na2SO4, the solvent was removed in vacuo and the product was reacted further without further purification.

후처리

  1. extractionextracted 3 times with 100 ml of EA
  2. dry with materialThe extract was dried over Na2SO4
  3. customthe solvent was removed in vacuo
  4. customthe product was reacted further without further purification

출처 및 근거

ORD 기록
ord-c09907fa8480465d82c3503d5247e916
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753710

반응 노트

불러오는 중…