1-Isobutylpiperazine dihydrochloride → 1-[4-(4-Fluorobenzyloxy)benzoyl]-4-isobutylpiperazine hydrochloride
반응식
[F:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][O:7][C:8]2[CH:25]=[CH:24][C:11]([C:12]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:16][CH2:15]3)=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[ClH:28].Cl.C(N1CCNCC1)C(C)C>>[ClH:28].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][C:8]2[CH:25]=[CH:24][C:11]([C:12]([N:14]3[CH2:15][CH2:16][N:17]([CH2:20][CH:21]([CH3:22])[CH3:23])[CH2:18][CH2:19]3)=[O:13])=[CH:10][CH:9]=2)=[CH:26][CH:27]=1참가 물질
3
실험 절차
As in the case of Example 22 which will be explained later, 1-[4-(4-fluorobenzyloxy)benzoyl]-4-isobutylpiperazine (compound of Example 5) (1.52 g) was converted into the corresponding hydrochloride salt, thereby yielding 1.65 g of the aimed compound.
출처 및 근거
- ORD 기록
- ord-a7b4154db0fe46979dbc7d65058dbab7
- 출처 데이터셋
- uspto-grants-1998_05