Ammonia → 4-Methoxyphenylbenzo[d]oxazole-4-carboxamide

HRID 1292138노트

반응식

HRID 1292138 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O:20]C)=O)[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1.[NH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([NH2:22])=[O:20])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 222Ammonia2회HCID 14616764Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate

생성물 1

HCID 183546064-Methoxyphenylbenzo[d]oxazole-4-carboxamide

실험 절차

Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate was dissolved in liquid ammonia (30 ml) and sealed in an autoclave. The reaction mixture was left at 55° C., 20 bar for >20 hours. Once the reaction was complete the ammonia was removed and the resulting solid recrystallised from boiling ethyl acetate and petrol.

후처리

  1. customsealed in an autoclave
  2. waitThe reaction mixture was left at 55° C.
  3. wait20 bar for >20 hours
  4. customwas removed
  5. customthe resulting solid recrystallised

출처 및 근거

ORD 기록
ord-08a35897cb694c50b8db1cc76a434d43
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756510

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