참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Nimesulide | HCID 4495 | — |
| 반응물 | L-Lysine | HCID 5962 | — |
| 반응물 | Gamma-cyclodextrin | HCID 5287407 | — |
| 반응물 | nimesulide L-lysine | HCID 9825177 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 131720676 | HCID 131720676 | — |
반응 단계
3 g of nimesulide (9.73×10-3 mole) are suspended in 200 ml of distilled water to which 3.2 g of L-lysine (1.95×10-2 mole) are added. The suspension is subjected to ultrasound for 5 minutes and then heated to 50° C. while violent agitation is maintained [Ultraturrax (registered mark)]. 13.88 g of γ-CD·7H2O (9.73×10-3 mole) are dispersed in 200 ml of distilled water and heated to 50° C. The suspension of γ-CD is added to the suspension of nimesulide+L-lysine. The agitation is continued for 15 minutes. An orangy solution is obtained. This solution is nebulized (Niro Atomizer Mobile atomizer) in the following conditions:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05756546 |
|---|
| 출처 데이터셋 | uspto-grants-1998_05 |
|---|
| ORD ID | ord-d52e7b91cb6d438493a11dc42c25e99b |
|---|
| 출처 메모 | uspto-grants-1998_05 |
|---|
