Thionyl Chloride → 2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride

HRID 1292342노트

반응식

HRID 1292342 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].S(Cl)([Cl:24])=O>C1COCC1>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([Cl:24])=[O:6]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 189141452-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoic acid

생성물 1

HCID 189141812-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoic acid (0.546 g, 1.86 mmol) in THF (10 ml) was stirred under nitrogen and treated with thionyl chloride (0.27 ml, 0.44 g, 3.7 mmol). The mixture was stirred at ambient temperature for 18 hours, then concentrated in vacuo to give 2-methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-bb3521b71abe4b33bb12b5b60ad74aa5
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756504

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