HCID 18915111, 화합물 → HCID 18915181, 화합물

HRID 1292441노트

반응식

HRID 1292441 반응식
[CH3:1][N:2]([CH2:4][CH:5]1[CH2:10][O:9][CH2:8][CH2:7][NH:6]1)[CH3:3].[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH:17]([C:21](Cl)=[O:22])[CH2:16][C:15]2=[O:24]>C(N(CC)CC)C>[ClH:11].[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH:17]([C:21]([N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH:5]1[CH2:4][N:2]([CH3:3])[CH3:1])=[O:22])[CH2:16][C:15]2=[O:24]

참가 물질

4

반응물 2

HCID 18915111HCID 18915111, 화합물HCID 18915134N,N-Dimethyl-3-morpholinemethanamine

생성물 1

HCID 18915181HCID 18915181, 화합물수율 122.7%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

The procedure described in Example 24 was repeated, but using 0.90 g of 3-dimethylaminomethylmorpholine, 2.3 ml of triethylamine and 1.03 g of 5-chloro-3-oxoindan-1-carbonyl chloride, to afford 1.03 g of the title compound, melting at 230°-240° C.

출처 및 근거

ORD 기록
ord-7c3f824ad66a4198bf5eec7d97af5a80
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756730

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