Ammonia → 2-amino N-(2-mercaptoethyl) propionamide

HRID 129248

반응식

HRID 129248 반응식
Cl.Cl.[NH2:3][C@H:4]([C:6](OCCN)=[S:7])C.C[C@@H:13]([OH:19])[C@H:14]([NH2:18])[C:15](O)=O.N>C(O)(C)C>[NH2:18][CH:14]([CH3:15])[C:13]([NH:3][CH2:4][CH2:6][SH:7])=[O:19]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 6288L-ThreonineHCID 88417728HCID 88417728, 화합물

생성물 1

HCID 98555172-amino N-(2-mercaptoethyl) propionamide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a suspension of 22.1 g of the 2-aminoethyl thioalaninate dihydrochloride (0.1 mole), obtained above, in 50 cm3 of isopropanol, thre are slowly added, under an inert atmosphere, 20.4 cm3 (0.15) mole) of a 2.5% aqueous ammonia solution. The resulting solution is evaporated to dryness under reduced pressure. The residue is taken up in 100 cm3 of ethanol. The insoluble ammonium chloride is separated by filtration on fritted glass. The filtrate is evaporated to dryness and dried under a vacuum at 50° C. 17.5 g of 2-amino N-(2-mercaptoethyl) propionamide in the form of a white solid whose melting point is 141° C. are obtained.

후처리

  1. customThe resulting solution is evaporated to dryness under reduced pressure
  2. customThe insoluble ammonium chloride is separated by filtration on fritted glass
  3. customThe filtrate is evaporated to dryness
  4. customdried under a vacuum at 50° C

출처 및 근거

ORD 기록
ord-e89a90da457e4b6dbe0ada3bbb4f82b4
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05466878

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