Hydrogen Peroxide → 4-Methoxyimino-5-methylthiochroman-6-carboxylic acid-1,1-dioxide

HRID 1292505

반응식

HRID 1292505 반응식
C[O:2]N=C1C2C(=CC=C(C(O)=O)C=2C)SCC1.[CH3:18][O:19][N:20]=[C:21]1[C:30]2[C:25](=[C:26](C)[CH:27]=[C:28]([C:32](C3C=NN(CC)C=3OS(CCC)(=O)=O)=[O:33])[C:29]=2[CH3:31])[S:24](=[O:50])(=[O:49])[CH2:23][CH2:22]1.OO.C(OCC)(=O)C>C(O)(=O)C>[CH3:18][O:19][N:20]=[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([C:32]([OH:33])=[O:2])[C:29]=2[CH3:31])[S:24](=[O:50])(=[O:49])[CH2:23][CH2:22]1

참가 물질

6

반응물 4

HCID 784Hydrogen PeroxideHCID 8857Ethyl AcetateHCID 537956584-Methoxyimino-5,8-dimethyl-6-(1-ethyl-5-n-propanesulfonyloxypyrazol-4-yl)carbonylthiochroman-1,1-dioxideHCID 539976794-Methoxyimino-5-methylthiochroman-6-carboxylic acid

생성물 1

HCID 539715404-Methoxyimino-5-methylthiochroman-6-carboxylic acid-1,1-dioxide수율 97%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

1.0 Gram (4.0 mmol) of the 4-methoxyimino-5-methylthiochroman-6-carboxylic acid obtained in the above (2) was reacted with 1.3 g (12 mmol) of a 30% hydrogen peroxide aqueous solution in 5 ml of acetic acid at 100° C. for 1 hour. Ethyl acetate was added to the reaction product, and the mixture was washed with a saturated sodium chloride aqueous solution and then dried over sodium sulfate. The solvent was distilled off to give 1.1 g (yield 97%) of 4-methoxyimino-5-methylthiochroman-6-carboxylic acid-1,1-dioxide.

후처리

  1. washthe mixture was washed with a saturated sodium chloride aqueous solution
  2. dry with materialdried over sodium sulfate
  3. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-b8ab6e12744041b5be5d81e82c49e22b
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756759

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