Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodobenzene → 2-[4-(3-Phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodobenzene | HCID 11575 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 2-(4-Prop-2-ynyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86619656 | — |
| 촉매 | Palladium Chloride | HCID 24290 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-[4-(3-Phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68431821 | 17.7% |
반응 단계
General procedure A was followed using the product from step 3, Example 1 (165 mg, 0.498 mmol), iodobenzene (85 mg, 0.416 mmol), PdCl2 (2.5 mg, 0.014 mmol), pyrrolidine (0.2 mL, 2.37 mmol), water (0.53 mL) to give the title compound (30 mg, 15%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728032B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-142f34a5b668407db154a9b24a229c5e |
| 출처 메모 | uspto-grants-2010_06 |