Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Bromo-4-iodobenzene → 2-{4-[3-(4-Bromo-phenyl)-prop-2-ynyloxy]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Bromo-4-iodobenzene | HCID 11522 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 2-(4-Prop-2-ynyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86619656 | — |
| 촉매 | Palladium Chloride | HCID 24290 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-{4-[3-(4-Bromo-phenyl)-prop-2-ynyloxy]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68429658 | 33.8% |
반응 단계
General procedure A was followed using the product from step 3 Example 1 (266 mg, 0.803 mmol), p-bromo iodobenzene (156.5 mg, 0.669 mmol), PdCl2 (2.5 mg, 0.014 mmol), pyrrolidine (0.277 mL, 3.34 mmol), water (0.844 mL) to give the title compound (110 mg, 33.8%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728032B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-f40eca44ce424484a1a2bde3e1058889 |
| 출처 메모 | uspto-grants-2010_06 |