Piperazine → o-Phenetidine

HRID 1292840

반응식

HRID 1292840 반응식
N1CCNCC1.BrCCOC(=O)[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH2:20][CH3:21].[N-]=C=O>CN(C=O)C>[CH2:20]([O:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[NH2:12])[CH3:21]

참가 물질

5

반응물 3

HCID 4837PiperazineHCID 105034IsocyanateHCID 111620142-bromoethyl-N-(2-ethoxyphenyl)carbamate

생성물 1

HCID 7203o-Phenetidine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

5 μl of TEA (0.033 mmol, 1.1 eq) is added then 500 μl of piperazine (0.03 mmol, 1 eq) dissolved in DMF to 300 μl of 0.2 M 2-bromoethyl-N-(2-ethoxyphenyl)carbamate (0.06 mmol, 2 eq) dissolved in DMF. After 18 hours at room temperature and evaporation of the solvents, the mixtures are taken up in 1 ml of CH2Cl2 and treated with isocyanate resin (Argonaut, 1.51 mmol/g, 0.09 mmol/g, 0.09 mmol, 3 eq) for 18 hours. Next, the mixtures are purified on cation exchange resins according to the protocol described hereinabove. The desired compounds are then obtained after elimination of the solvents.

후처리

  1. customevaporation of the solvents
  2. customNext, the mixtures are purified on cation exchange resins

출처 및 근거

ORD 기록
ord-29cfcdddbd9f4490814f1268c90c7ff3
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238693B2

연결된 노트

불러오는 중…