Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 2,4-Dichloro-6-(2,4-difluoro-phenoxy)-quinazoline | HCID 58820195 | — |
| 생성물 | 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine | HCID 58905130 | — |
반응 단계
Compound (1F) (21 g, 0.06 mol) was suspended in ammonia (100 mL of 2.0 M solution in MeOH) and the solution formed after 30 min was stirred at room temperature for 18 h. The precipitate was filtered, the concentrated filtrate triturated with EtOAc, and the organic layers were combined to yield 21.5 g of 2-chloro-6-(2,4-difluorophenoxy)-quinazolin-4-ylamine (1G).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07238698B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-9a55840aab77422bbbf1d8a693a522b8 |
| 출처 메모 | uspto-grants-2007_07 |