Triethylamine → 3-(8-Azabicyclo[3.2.1]octan-8-yl)sulfonyl-1-dimethylcarbamoyl-1H-1,2,4-triazole

HRID 1293148

반응식

HRID 1293148 반응식
Cl[S:2]([C:5]1[N:9]=[CH:8][N:7]([C:10](=[O:14])[N:11]([CH3:13])[CH3:12])[N:6]=1)(=[O:4])=[O:3].Cl.[CH:16]12[NH:23][CH:20]([CH2:21][CH2:22]1)[CH2:19][CH2:18][CH2:17]2.C(N(CC)CC)C>C(OCC)(=O)C>[CH:20]12[N:23]([S:2]([C:5]3[N:9]=[CH:8][N:7]([C:10](=[O:14])[N:11]([CH3:13])[CH3:12])[N:6]=3)(=[O:4])=[O:3])[CH:16]([CH2:22][CH2:21]1)[CH2:17][CH2:18][CH2:19]2

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 5222728-Azabicyclo[3.2.1]octane hydrochlorideHCID 178387483-chlorosulfonyl-1-dimethylcarbamoyl-1H-1,2,4-triazole

생성물 1

HCID 589054543-(8-Azabicyclo[3.2.1]octan-8-yl)sulfonyl-1-dimethylcarbamoyl-1H-1,2,4-triazole수율 24.3%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 3-chlorosulfonyl-1-dimethylcarbamoyl-1H-1,2,4-triazole (Example 54-a) (470 mg), 8-azabicyclo[3.2.1]octane hydrochloride (350 mg), triethylamine (0.7 ml), and ethyl acetate (10 ml) was stirred overnight at room temperature. The reaction solution was washed with water, followed by saturated aqueous sodium chloride solution, and concentrated. The residue was subjected to a silica-gel column chromatography with 50 to 100% ethyl acetate/hexane to yield the title compound (150 mg).

후처리

  1. washThe reaction solution was washed with water
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-808be267f9064c308abe3a533da335b4
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238720B2

연결된 노트

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