3-Fluorophenol → 5-Fluoro-2-(3-fluorophenoxy)nicotinic acid

반응식

[OH:1][C:2]1[N:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:12][C:13]1[CH:14]=[C:15](O)[CH:16]=[CH:17][CH:18]=1>>[F:11][C:8]1[CH:9]=[N:10][C:2]([O:1][C:17]2[CH:16]=[CH:15][CH:14]=[C:13]([F:12])[CH:18]=2)=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

참가 물질

반응물 2

HCID 97433-Fluorophenol

HCID 178524531HCID 178524531, 화합물

생성물 1

HCID 575723475-Fluoro-2-(3-fluorophenoxy)nicotinic acid

실험 절차

The title compound was prepared according to the procedure described in step 1 & 2 of Example 1 from 2-hydroxy-5-fluoronicotinic acid and 3-fluorophenol; 1H-NMR (DMSO-d6) δ 8.37 (1H, m), 8.23–8.15(1H, m), 7.49–7.35 (1H, m), 7.10–6.90 (3H, m).

출처 및 근거

ORD 기록: ord-fe13eb87f0314c38b05c773ec28186bb
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07238714B2

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