Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-chlorobenzyl)nicotinate

HRID 1293209노트

반응식

HRID 1293209 반응식
Cl[C:2]1[N:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Cl-].[Cl:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=1)[CH2:18][Zn+]>>[Cl:12][C:9]1[CH:10]=[N:11][C:2]([CH2:18][C:17]2[CH:20]=[CH:21][CH:22]=[C:15]([Cl:14])[CH:16]=2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

참가 물질

3

반응물 2

HCID 2764318Methyl 2,5-DichloronicotinateHCID 178478087HCID 178478087, 화합물

생성물 1

HCID 57572306Methyl 5-chloro-2-(3-chlorobenzyl)nicotinate

실험 절차

The title compound was prepared according to the procedure described in step 2 of Example 58 from methyl 2,5-dichloronicotinate and 3-chlorobenzylzinc chloride: 1H-NMR (CDCl3) δ 8.65 (1H, d, J=2.6 Hz), 8.17 (1H, d, J=2.6 Hz), 7.26–7.12 (4H, m), 4.52 (2H, s), 3.89 (3H, s).

출처 및 근거

ORD 기록
ord-ca5931eefde24aaaab44fc0110a31838
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238714B2

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