3-Fluorophenol → Methyl 5-chloro-2-(3-fluorophenoxy)benzoate

HRID 1293225노트

반응식

HRID 1293225 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:13][C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([F:13])[CH:15]=2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

참가 물질

3

반응물 2

HCID 97433-FluorophenolHCID 21525433Methyl 5-chloro-2-fluorobenzoate

생성물 1

HCID 57572274Methyl 5-chloro-2-(3-fluorophenoxy)benzoate

실험 절차

The title compound was prepared according to the procedure described in step 1 of Example 67 from methyl 5-chloro-2-fluorobenzoate and 3-fluorophenol: 1H-NMR (CDCl3) δ 7.91 (1H, d, J=2.8 Hz), 7.46 (1H, dd, J=8.7, 2.8 Hz), 7.31–7.06 (1H, m), 6.99 (1H, d, J=8.7 Hz), 6.83–6.61 (3H, m), 3.81 (3H, s).

출처 및 근거

ORD 기록
ord-854c2b0e2a5e4a13b294bce9449398c5
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238714B2

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