반응식
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:26])=[CH:4][N:3]=1.[F:27][C:28]1[CH:29]=[C:30]([OH:35])[CH:31]=[C:32]([F:34])[CH:33]=1>>[Cl:26][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:35][C:30]2[CH:29]=[C:28]([F:27])[CH:33]=[C:32]([F:34])[CH:31]=2)=[N:3][CH:4]=1참가 물질
3
실험 절차
The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and 3,5-difluorophenol: 1H-NMR (CDCl3) δ 8.53 (1H, d, J=2.6 Hz), 8.18 (1H, d, J=2.6 Hz), 7.95 (1H, dd, J=6.8, 1.8 Hz), 7.38 (2H, d, J=8.1 Hz), 6.83–6.69 (2H, m), 6.40–6.32 (2H, m), 6.25 (1H, br.s), 5.39–5.30 (1H, m), 1.60 (3H, d, J=6.2 Hz), 1.59 (9H, s).
출처 및 근거
- ORD 기록
- ord-30cc877899a04e8085d441f785f7c845
- 출처 데이터셋
- uspto-grants-2007_07
- 특허 번호
- US07238714B2
연결된 노트
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